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Allergol Int. 2010 Jun;59(2):143-60. doi: 10.2332/allergolint.10-RAI-0186. Epub 2010 Apr 24.

IL-33 and IL-33 receptors in host defense and diseases.

Author information

1
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

Abstract

Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18. IL-33 is considered to be crucial for induction of Th2-type cytokine-associated immune responses such as host defense against nematodes and allergic diseases by inducing production of such Th2-type cytokines as IL-5 and IL-13 by Th2 cells, mast cells, basophils and eosinophils. In addition, IL-33 is involved in the induction of non-Th2-type acute and chronic inflammation as a proinflammatory cytokine, similar to IL-1 and IL-18. In this review, we summarize and discuss the current knowledge regarding the roles of IL-33 and IL-33 receptors in host defense and disease development.

PMID:
20414050
DOI:
10.2332/allergolint.10-RAI-0186
[Indexed for MEDLINE]
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