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J Med Genet. 2010 Apr;47(4):268-70. doi: 10.1136/jmg.2009.073544.

A BRCA1 promoter variant (rs11655505) and breast cancer risk.

Author information

1
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. paolo.radice@istitutotumori.mi.it

Abstract

BACKGROUND:

A study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.-2265C-->T) increases promoter activity and has a protective effect on breast cancer risk.

METHODS:

We genotyped rs11655505 in 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies.

RESULTS:

No evidence for an association between rs11655505 and breast cancer risk was found.

CONCLUSIONS:

Our study failed to confirm a role of rs11655505 in breast cancer risk. Larger studies are necessary to determine if there is a weak association between this SNP and breast cancer risk.

PMID:
20413709
DOI:
10.1136/jmg.2009.073544
[Indexed for MEDLINE]

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