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Psychiatry Res. 2010 May 30;182(2):180-2. doi: 10.1016/j.pscychresns.2009.12.003. Epub 2010 Apr 21.

Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot study.

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Melbourne Neuropsychiatry Centre, University of Melbourne, Australia.


We used magnetic resonance imaging to examine the effect of ethyl-eicosapentaenoic acid (E-EPA) on hippocampal T(2) relaxation time in first episode psychosis patients at baseline and after 12 weeks of follow-up. There was an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a neuroprotective effect of E-EPA treatment. In addition, the smaller the increase in T(2), the greater the improvement in negative symptoms.

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