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Cell Host Microbe. 2010 Apr 22;7(4):257-9. doi: 10.1016/j.chom.2010.04.002.

Cathelicidins link the endocrine and immune systems.

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1
Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

Abstract

Cathelicidin peptides play key roles in host responses to infection. Radek and colleagues (2010) demonstrate that the nicotinic acetylcholine system, activated during stress, suppresses production of mouse cathelicidin, increasing host susceptibility to the pathogen Staphylococcus aureus. This suggests a distinct way by which the endocrine system regulates innate immunity.

PMID:
20413092
DOI:
10.1016/j.chom.2010.04.002
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