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FEBS Lett. 2010 Jun 18;584(12):2606-17. doi: 10.1016/j.febslet.2010.04.043. Epub 2010 Apr 20.

A structural classification of substrate-binding proteins.

Author information

1
Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.

Abstract

Substrate-binding proteins (SBP) are associated with a wide variety of protein complexes. The proteins are part of ATP-binding cassette transporters for substrate uptake, ion gradient driven transporters, DNA-binding proteins, as well as channels and receptors from both pro- and eukaryotes. A wealth of structural and functional data is available on SBPs, with over 120 unique entries in the Protein Data Bank (PDB). Over a decade ago these proteins were divided into three structural classes, but based on the currently available wealth of structural data, we propose a new classification into six clusters, based on features of their three-dimensional structure.

PMID:
20412802
DOI:
10.1016/j.febslet.2010.04.043
[Indexed for MEDLINE]
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