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Dev Cell. 2010 Apr 20;18(4):506-7. doi: 10.1016/j.devcel.2010.04.005.

Realizing the promise of RNAi high throughput screening.

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Dynamical Cell Systems Team, Section of Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.


Recently reporting in Nature, Collinet et al. describes the application of quantitative multiparametric methods to a genome-wide RNAi screen for regulators of endocytosis. The study illustrates the power of this approach beyond the identification of new endocytic components to providing insights into the design principles of the endocytic system.

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