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Sci Transl Med. 2010 Apr 21;2(28):28ps19. doi: 10.1126/scitranslmed.3001056.

Drug resistance, epigenetics, and tumor cell heterogeneity.

Author information

1
OncoMed Pharmaceuticals, Redwood City, CA 94063, USA. Tim.Hoey@oncomed.com

Abstract

The resistance of cancer cells to various therapeutic agents and modalities is a crucial issue in clinical oncology. A recent Cell paper highlights how changes at the chromatin level control drug sensitivity and provides insight into more effective strategies for treating cancer with combination therapies.

PMID:
20410528
DOI:
10.1126/scitranslmed.3001056
[Indexed for MEDLINE]

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