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Psychosom Med. 2010 Jul;72(6):527-34. doi: 10.1097/PSY.0b013e3181dbbb7d. Epub 2010 Apr 21.

Depressive symptoms and mortality in patients after kidney transplantation: a prospective prevalent cohort study.

Author information

1
Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary. marta@nefros.net

Abstract

OBJECTIVE:

To analyze in a prospective cohort study if depressive symptoms are an independent predictor of mortality in kidney transplant recipients.

METHODS:

Data from 840 transplanted patients followed at a single outpatient transplant center were analyzed. Sociodemographic parameters and clinical data were collected at enrollment (between August 2002 and February 2003). Participants completed the Center for Epidemiologic Studies-Depression (CES-D) scale. Depression was defined as CES-D score of > or = 18. Data on 5-year outcomes (death censored graft loss or mortality) were collected.

RESULTS:

The prevalence of depression was 22%. Mortality was higher (21% versus 13%; p = .004) in patients with versus without depression. In a multivariate Cox proportional hazard model, both the baseline CES-D score (hazard ratio(for each 1-point increase) = 1.02; 95% confidence interval, 1.00-1.04) and the presence of depression at baseline (hazard ratio(presence) = 1.66; 95% confidence interval, 1.12-2.47) were significantly associated with mortality. The baseline CES-D score also significantly predicted death censored graft loss (hazard ratio(for each 1-point increase) = 1.03; 95% confidence interval, 1.01-1.05).

CONCLUSION:

Depressive symptoms are an independent predictor of mortality in kidney transplanted patients.

PMID:
20410250
DOI:
10.1097/PSY.0b013e3181dbbb7d
[Indexed for MEDLINE]
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