Format

Send to

Choose Destination
Expert Rev Respir Med. 2010 Apr;4(2):171-7. doi: 10.1586/ers.10.15.

Aerosol and nasal delivery of vaccines and antiviral drugs against seasonal and pandemic influenza.

Author information

1
Defence R&D Canada-Suffield, Box 4000 Station Main, Medicine Hat, Alberta T1A8K6, Canada. jonathan.wong@drdc-rddc.gc.ca

Abstract

Influenza is primarily a respiratory tract infection involving the exacerbation and inflammation of the respiratory tract, which can progress to life-threatening pneumonia, hypercytokinemia, edema, acute lung injury, respiratory failure and death. Viral mutations and drug resistance are the leading challenges in influenza prevention and treatment. Aerosol inhalation provides rapid availability and sustained therapeutic levels of antiviral drugs in the respiratory tract, without causing a systemic burden to unaffected tissues and organs. Furthermore, aerosol delivery enhances the bioavailability of antiviral drugs with poor oral adsorption. Nasal spray delivery of vaccines provides a safe and needle-free means of vaccination, and contains live-attenuated virus that induces mucosal immunity and provides long-lasting immunity relative to injectable inactivated vaccines. Since influenza is a disease with respiratory clinical manifestations, specific delivery of antiviral drugs or vaccines to the respiratory tract may represent a safe and effective approach to combat influenza.

PMID:
20406083
DOI:
10.1586/ers.10.15
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center