Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Res. 2010 Jun;20(6):614-21. doi: 10.1038/cr.2010.53. Epub 2010 Apr 20.

New insights into p53 activation.

Author information

1
Stemline Therapeutics, Inc., Suite 34-L, New York, NY 10128, USA. cbrooks@stemline.com

Abstract

The tumor suppressor p53 is a multifunctional, highly regulated, and promoter-specific transcriptional factor that is uniquely sensitive to DNA damage and cellular stress signaling. The mechanisms by which p53 directs a damaged cell down either a cell growth arrest or an apoptotic pathway remain poorly understood. Evidence suggests that the in vivo functions of p53 seem to balance the cell-fate choice with the type and severity of damage that occurs. The concept of antirepression, or inhibition of factors that normally keep p53 at bay, may help explain the physiological mechanisms for p53 activation. These factors also provide novel chemotherapeutic targets for the reactivation of p53 in tumors harboring a wild-type copy of the gene.

PMID:
20404858
PMCID:
PMC3070262
DOI:
10.1038/cr.2010.53
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center