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FEMS Microbiol Lett. 1991 Mar 1;62(2-3):239-44.

A toxic shock syndrome toxin mutant of Staphylococcus aureus isolated by allelic replacement lacks virulence in a rabbit uterine model.

Author information

1
Microbiology Department, Moyne Institute, Trinity College, Dublin, Ireland.

Abstract

The gene coding for toxic shock syndrome toxin-1 in S. aureus was inactivated by allelic replacement in two TSS-associated strains. One mutant derived from FRI1169 (a non-enterotoxigenic strain) lacked virulence in the rabbit uterine chamber infection model. This suggests that TSST-1 is the only determinant produced by this strain that can induce the symptoms of shock in rabbits. A novel method for allelic replacement involving transduction of plasmid integrants is described.

PMID:
2040432
DOI:
10.1016/0378-1097(91)90164-6
[Indexed for MEDLINE]

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