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J Cell Biol. 2010 Apr 19;189(2):197-9. doi: 10.1083/jcb.201003032.

Cyclin B-Cdk1 activates its own pump to get into the nucleus.

Author information

1
Department of Medical Oncology, University Medical Center Utrecht, 3584CG Utrecht, Netherlands. a.lindqvist@umcutrecht.nl

Abstract

The transition to mitosis requires extensive nuclear and cytoplasmic rearrangements that must be spatially and temporally coordinated. In this issue, Gavet and Pines (2010a. J. Cell Biol. doi:10.1083/jcb.200909144) report on a simple yet elegant mechanism as to how this is achieved. By monitoring the activity of cyclin B-Cdk1 in real time, the authors show that concomitant with its activation in the cytoplasm, the kinase complex is rapidly imported into the nucleus by modifying the activity of the nucleocytoplasmic transport machinery. Thus, cyclin B-Cdk1 activates its own pump to get into the nucleus.

PMID:
20404105
PMCID:
PMC2856906
DOI:
10.1083/jcb.201003032
[Indexed for MEDLINE]
Free PMC Article

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