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Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1663-78. doi: 10.1098/rstb.2010.0026.

Spermatogonial stem cell regulation and spermatogenesis.

Author information

1
Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, 204 Craft Avenue, Pittsburgh, PA, USA.

Abstract

This article will provide an updated review of spermatogonial stem cells and their role in maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial stem cells (SSCs) will be described, along with research using these tools to enhance our understanding of stem cell biology and spermatogenesis. Increased knowledge about the biology of SSCs improves our capacity to manipulate these cells for practical application. The chapter concludes with a discussion of future directions for fundamental investigation and practical applications of SSCs.

PMID:
20403877
PMCID:
PMC2871929
DOI:
10.1098/rstb.2010.0026
[Indexed for MEDLINE]
Free PMC Article

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