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Semin Cell Dev Biol. 2010 Sep;21(7):671-6. doi: 10.1016/j.semcdb.2010.04.002. Epub 2010 Apr 18.

Regulation of membrane biogenesis in autophagy via PI3P dynamics.

Author information

1
Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, Japan. takenoda@biken.osaka-u.ac.jp

Abstract

In autophagy, cytoplasmic substrates are targeted for degradation in the lysosome via membrane structures called autophagosomes. The formation of the autophagosome is the primary regulatory point for autophagy activity, and PI3P plays a central role in this process. In this review, we will discuss the role of PI3P in autophagosome formation from three different perspectives: PI3-kinase, PI3-binding proteins, and PI3-phosphatase. Recent developments in this field suggest that the local PI3P concentration is dynamically regulated during autophagy, and that this molecule is critical to the proper control of autophagy.

PMID:
20403452
DOI:
10.1016/j.semcdb.2010.04.002
[Indexed for MEDLINE]

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