Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2010 Apr 16;141(2):355-67. doi: 10.1016/j.cell.2010.02.036.

A role for codon order in translation dynamics.

Author information

1
Institute of Computational Science, ETH Zurich, 8092 Zurich, Switzerland.

Erratum in

  • Cell. 2010 May 14;141(4):728. Cannarrozzi, Gina [corrected to Cannarozzi, Gina].

Abstract

The genetic code is degenerate. Each amino acid is encoded by up to six synonymous codons; the choice between these codons influences gene expression. Here, we show that in coding sequences, once a particular codon has been used, subsequent occurrences of the same amino acid do not use codons randomly, but favor codons that use the same tRNA. The effect is pronounced in rapidly induced genes, involves both frequent and rare codons and diminishes only slowly as a function of the distance between subsequent synonymous codons. Furthermore, we found that in S. cerevisiae codon correlation accelerates translation relative to the translation of synonymous yet anticorrelated sequences. The data suggest that tRNA diffusion away from the ribosome is slower than translation, and that some tRNA channeling takes place at the ribosome. They also establish that the dynamics of translation leave a significant signature at the level of the genome.

PMID:
20403329
DOI:
10.1016/j.cell.2010.02.036
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center