Format

Send to

Choose Destination
J Neurochem. 2010 Jul;114(1):13-27. doi: 10.1111/j.1471-4159.2010.06736.x. Epub 2010 Apr 6.

Toll-like receptor 4 in CNS pathologies.

Author information

1
Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado 80309-0215, USA.

Abstract

The responses of the brain to infection, ischemia and trauma share remarkable similarities. These and other conditions of the CNS coordinate an innate immune response marked by activation of microglia, the macrophage-like cells of the nervous system. An important contributor to microglial activation is toll-like receptor 4, a pathogen-associated molecular pattern receptor known to initiate an inflammatory cascade in response to various CNS stimuli. The present review traces new efforts to characterize and control toll-like receptor 4 in inflammatory etiologies of the nervous system.

PMID:
20402965
PMCID:
PMC2909662
DOI:
10.1111/j.1471-4159.2010.06736.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center