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Med Chem. 2010 Jan;6(1):6-8.

Synthesis and preliminary biological evaluation of chrysin derivatives as potential anticancer drugs.

Author information

1
Institute of Pharmacy & Pharmacology, University of South China, Hengyang, 421001, China. zhengxing5018@yahoo.com

Abstract

A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6-trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.

PMID:
20402655
DOI:
10.2174/157340610791208763
[Indexed for MEDLINE]

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