Format

Send to

Choose Destination
Int J Neurosci. 2010 May;120(5):386-95. doi: 10.3109/00207450802336683.

Serotonin-induced region-specific responses of the arcuate and ventromedial hypothalamic nuclei.

Author information

1
Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, California 90502, USA.

Abstract

The arcuate nucleus (ARC) modulates both satiety and hunger signals at the lateral and medial sites, respectively, though these competing responses may be both mediated by serotonin (5-HT). We sought to determine region-specific effects of 5-HT on ARC neurons. Electrical activities in rat hypothalamic slices were simultaneously recorded with an extracellular multielectrode array. 5-HT effects on the ARC were region-specific: primary inhibition of medial ARC and stimulation of lateral ARC neurons. 5-HT primarily inhibited ventromedial nucleus neurons. These results suggest ARC region-specific responses to 5-HT consistent with the anatomical location of lateral ARC anorexigenic proopiomelanocortin neurons and medial ARC orexigenic neuropeptide Y neurons.

PMID:
20402579
DOI:
10.3109/00207450802336683
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center