Format

Send to

Choose Destination
See comment in PubMed Commons below
Tex Heart Inst J. 2010;37(2):149-58.

Antithrombotic therapy for the CardioWest temporary total artificial heart.

Author information

1
Department of Pharmacy, Comprehensive Transplant Center, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA. censor1@jhmi.edu

Abstract

The CardioWest temporary total artificial heart serves as a viable bridge to orthotopic heart transplantation in patients who are experiencing end-stage refractory biventricular heart failure. This device is associated with a low, albeit still substantial, risk of thrombosis. Platelet interactions with artificial surfaces are complex and result in continuous activation of contact proteins despite therapeutic anticoagulation. We searched the medical literature (publication dates, January 1962-October 2009) in order to evaluate means of mitigating adverse events that have occurred after implantation of the CardioWest temporary total artificial heart.We conclude that the use of a multitargeted antithrombotic approach, involving anticoagulation (bivalirudin and warfarin) and antiplatelet therapy (dipyridamole and aspirin), can mitigate the procoagulative effects of mechanical circulatory assist devices, particularly those that are associated with the CardioWest temporary total artificial heart. Careful monitoring with use of a variant multisystem approach, involving efficacy tests (thrombelastography and light transmittance aggregometry), safety tests (laboratory analyses), and warfarin genomics, may maximize the therapeutic actions and minimize the bleeding risks that are associated with the multitargeted antithrombotic approach. The development and monitoring of individualized antithrombotic regimens require that informed health professionals appreciate the complexities and grasp the hazards that are associated with these therapies.

KEYWORDS:

Anticoagulants/administration & dosage/pharmacokinetics/therapeutic use; antithrombins/administration & dosage/therapeutic use; combined modality therapy; complement activation; equipment design; fibrinolytic agents/therapeutic use; heart failure/therapy; heart, artificial/adverse effects/trends; heart-assist devices/adverse effects; platelet aggregation; thrombelastography; thromboembolism/etiology/prevention & control

PMID:
20401285
PMCID:
PMC2851409
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center