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J Cyst Fibros. 2010 Jul;9(4):272-6. doi: 10.1016/j.jcf.2010.03.008. Epub 2010 Apr 18.

Lung transplantation in patients with cystic fibrosis and Mycobacterium abscessus infection.

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1
Department of Respiratory Medicine and Allergology, Bruna Stråket 11b, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden. marita.gilljam@lungall.gu.se

Abstract

Mycobacterium abscessus lung disease is difficult to treat and has been considered a strong relative contraindication to lung transplantation. We performed double lung transplantation in three cystic fibrosis patients with ongoing, and a fourth with recent treatment for Mycobacterium abscessus lung infection. Despite prolonged antibiotic courses and adjustment of immunosuppressive therapy the first three patients developed skin infection and abscesses. At follow-up after 1, 3, 5 and 7years respectively no patient had evidence of M abscessus infection and all had stable lung function. Lung transplantation in patients with M abscessus lung infection is feasible but may involve severe complications.

PMID:
20400381
DOI:
10.1016/j.jcf.2010.03.008
[Indexed for MEDLINE]
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