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Bioorg Med Chem Lett. 2010 May 15;20(10):3125-8. doi: 10.1016/j.bmcl.2010.03.106. Epub 2010 Apr 3.

1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.

Author information

1
Pfizer Global Research and Development, Chesterfield, MO 63017, United States. michael.tollefson@yahoo.com

Abstract

1H-Pyrazolo[4,3-d]pyrimidines were previously disclosed as a potent second generation class of phosphodiesterase 5 (PDE5) inhibitors. This work explores the advancement of more selective and potent PDE5 inhibitors resulting from the substitution of 2-(2,2,2-trifluoroethoxy)ethyl at the 1 position in the so-called alkoxy pocket.

PMID:
20400309
DOI:
10.1016/j.bmcl.2010.03.106
[Indexed for MEDLINE]

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