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Adv Cancer Res. 2010;107:137-62. doi: 10.1016/S0065-230X(10)07005-3.

Androgen regulation of gene expression.

Author information

1
Department of Urology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

Abstract

The biological action of androgenic male sex steroid hormones in prostate tissue is mediated by the androgen receptor, a nuclear transcription factor. The transcriptional program of androgenic signaling in the prostate consists of thousands of gene targets whose products play a role in almost all cellular functions, including cellular proliferation, survival, lipid metabolism, and differentiation. This review will provide a summary of the most recent data regarding androgen-regulated target genes and modulation of androgen receptor activity, especially with regard to androgen-dependent and castration-recurrent prostate cancer.

PMID:
20399963
DOI:
10.1016/S0065-230X(10)07005-3
[Indexed for MEDLINE]

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