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Genome Biol. 2010;11(4):R43. doi: 10.1186/gb-2010-11-4-r43. Epub 2010 Apr 16.

Flux balance analysis accounting for metabolite dilution.

Author information

1
The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel. tomerbe1@post.tau.ac.il

Abstract

Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required for balancing their dilution leads flux balance analysis to false predictions in some cases. Here, we present metabolite dilution flux balance analysis, which addresses this problem, resulting in improved metabolic phenotype predictions.

PMID:
20398381
PMCID:
PMC2884546
DOI:
10.1186/gb-2010-11-4-r43
[Indexed for MEDLINE]
Free PMC Article

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