Send to

Choose Destination
See comment in PubMed Commons below
Lett Drug Des Discov. 2010 Jan 1;7(1):57-62.

Homology Modelling of Human E1 Ubiquitin Activating Enzyme.

Author information

Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, Wales, CF10 3NB, U.K.


Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center