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Lett Drug Des Discov. 2010 Jan 1;7(1):57-62.

Homology Modelling of Human E1 Ubiquitin Activating Enzyme.

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1
Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, Wales, CF10 3NB, U.K.

Abstract

Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.

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