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Mediators Inflamm. 2010;2010:758656. doi: 10.1155/2010/758656. Epub 2010 Apr 8.

Mediators of inflammation in polycystic ovary syndrome in relation to adiposity.

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1
Academic Endocrinology, Diabetes and Metabolism, Hull York Medical School, Michael White Diabetes Centre, 220-236 Analby Road, Hull Royal Infirmary, Hull HU32JZ, UK. thozhukat.sathyapalan@hyms.ac.uk

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age group and is associated with a higher cardiovascular risk. Obesity, mainly visceral adiposity, is prevalent in patients with PCOS. Obesity is associated with low-grade inflammation and raised inflammatory cytokines, both of which are also described in patients with PCOS. In this paper, the potential relationships between fat distribution, adipocyte dysfunction and, altered inflammatory markers in patients with PCOS have been discussed.

PMID:
20396393
PMCID:
PMC2852606
DOI:
10.1155/2010/758656
[Indexed for MEDLINE]
Free PMC Article
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