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Beijing Da Xue Xue Bao. 2010 Apr 18;42(2):238-42.

[Dual-role regulations of canonical Wnt/beta-catenin signaling pathway].

[Article in Chinese]

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06 Class of Stomatology, Department of Biochemistry and Molecular Biology, Peking University School of Basic Medical Science, Beijing 100191, China.


In recent years, Wnt/beta-catenin signaling has been identified as a key player in embryogenesis and human diseases. Canonical Wnt signaling pathway is controlled by a variety of classic molecules like Wnt, beta-catenin, Axin, APC, GSK-3beta and CK1, which interact and coordinate to regulate the expressions of cell signaling molecules. The latest evidences suggest that some components of the Wnt/beta-catenin signaling, like APC, GSK-3beta, CK1, Dkk2 and WISE, play dual roles different from what they have been thought previously. Here we reviewed some recent discoveries on the canonical Wnt/beta-catenin signaling pathway to provide some new ideas and principles for signaling transduction studies.

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