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Biol Chem Hoppe Seyler. 1991 Jan;372(1):63-8.

Chemical synthesis of new trypsin, chymotrypsin and elastase inhibitors by amino-acid substitutions in a trypsin inhibitor from squash seeds (CMTI III).

Author information

1
Institute of Chemistry, University of GdaƄsk, Poland.

Abstract

Five new analogues of squash trypsin inhibitor CMTI III were obtained by the solid-phase method, exhibiting antitrypsin, antichymotrypsin or antielastase activity. Modification in the reactive site region changes dramatically the specificity, whereas substitution in non-contact positions facilitates the refolding of the reduced form of the peptides and does not have a significant influence on the association equilibrium constants of the inhibitor analogues with cognate enzymes.

PMID:
2039608
[Indexed for MEDLINE]

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