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Nat Rev Genet. 2010 May;11(5):356-66. doi: 10.1038/nrg2760.

Genome-wide association studies in diverse populations.

Author information

1
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. rnoah@umich.edu

Abstract

Genome-wide association (GWA) studies have identified a large number of SNPs associated with disease phenotypes. As most GWA studies have been performed in populations of European descent, this Review examines the issues involved in extending the consideration of GWA studies to diverse worldwide populations. Although challenges exist with issues such as imputation, admixture and replication, investigation of a greater diversity of populations could make substantial contributions to the goal of mapping the genetic determinants of complex diseases for the human population as a whole.

PMID:
20395969
PMCID:
PMC3079573
DOI:
10.1038/nrg2760
[Indexed for MEDLINE]
Free PMC Article

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