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Rev Med Interne. 2010 Jun;31(6):411-6. doi: 10.1016/j.revmed.2009.08.006. Epub 2010 Apr 14.

[Chronic inflammatory demyelinating polyradiculoneuropathy].

[Article in French]

Author information

1
Centre de référence pour la prise en charge des maladies neuromusculaires et de la SLA, hôpital de la Timone, CHU de Marseille, 264, rue Saint-Pierre, 13385 Marseille, France.

Abstract

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a demyelinating chronic neuropathy of immune origin whose diagnosis is based upon clinical, biological and electrophysiological data; previously critical to the diagnosis the nerve biopsy is now restricted to the rare situations where accurate diagnosis cannot be reached using these data alone. CIDP are mainly idiopathic, but a few associated diseases must be sought for as they require specific attention. Such associated diseases must particularly be discussed when the manifestations are severe or resistant to immunomodulating or immunosuppressive agents. Indeed, idiopathic CIDP are usually responsive to these treatments. The effectiveness of these treatments is limited by the importance of the secondary axonal loss. The dependence or the resistance may sometimes justify the association of several immunomodulating treatments. A single randomized controlled trial support the use of cytotoxic drugs and none with rituximab.

PMID:
20395023
DOI:
10.1016/j.revmed.2009.08.006
[Indexed for MEDLINE]

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