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Trends Genet. 2010 May;26(5):221-30. doi: 10.1016/j.tig.2010.02.001. Epub 2010 Apr 13.

Molecular diversity through RNA editing: a balancing act.

Author information

1
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA.

Abstract

RNA editing by adenosine deamination fuels the generation of RNA and protein diversity in eukaryotes, particularly in higher organisms. This includes the recoding of translated exons, widespread editing of retrotransposon-derived repeat elements and sequence modification of microRNA (miRNA) transcripts. Such changes can bring about specific amino acid substitutions, alternative splicing and changes in gene expression levels. Although the overall prevalence of adenosine-to-inosine (A-to-I) editing and its specific functional impact on many of the affected genes is not yet known, the importance of balancing RNA modification levels across time and space is becoming increasingly evident. In particular, transcriptome instabilities in the form of too much or too little RNA editing activity, or misguided editing, manifest in several human disease phenotypes and can disrupt that balance.

PMID:
20395010
PMCID:
PMC2865426
DOI:
10.1016/j.tig.2010.02.001
[Indexed for MEDLINE]
Free PMC Article

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