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Clin Cardiol. 2010 Apr;33(4):222-7. doi: 10.1002/clc.20724.

Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease.

Author information

1
Department of Cardiac Care Unit, The First Affiliated Hospital of Harbin Medical University, Harbin, China. wlfeng@hotmail.com

Abstract

BACKGROUND:

HMG-CoA reductase inhibitors (statins) have antiatherogenic effects beyond their cholesterol-lowing effect. Whether atorvastatin has a stronger antioxidant effect than other statins is uncertain.

HYPOTHESIS:

To determine the effects of simvastatin and atorvastatin on markers of oxidative stress in patients with coronary heart disease (CHD).

METHODS:

This study was comprised of 164 patients with CHD and a control population of 122 healthy subjects. The patients with CHD were divided into 2 groups and treated with either simvastatin 20 mg/day or atorvastatin 10 mg/day. The markers of oxidative stress were measured before and after 12 weeks of treatment.

RESULTS:

The effects of atorvastatin on reducing oxidative stress were significantly greater compared with those of simvastatin (P < 0.05). The changes in the markers of oxidative stress did not correlate with the changes in the plasma lipid profile (P > 0.05).

CONCLUSIONS:

This study suggests that atorvastatin reduces oxidative stress more effectively than simvastatin.

PMID:
20394043
DOI:
10.1002/clc.20724
[Indexed for MEDLINE]
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