Format

Send to

Choose Destination
See comment in PubMed Commons below
Can J Physiol Pharmacol. 2010 Mar;88(3):264-72. doi: 10.1139/Y10-014.

Dealing with oxidative stress and iron starvation in microorganisms: an overview.

Author information

1
Department of Biochemistry, RNA Group, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.

Abstract

Iron starvation and oxidative stress are 2 hurdles that bacteria must overcome to establish an infection. Pathogenic bacteria have developed many strategies to efficiently infect a broad range of hosts, including humans. The best characterized systems make use of regulatory proteins to sense the environment and adapt accordingly. For example, iron-sulfur clusters are critical for sensing the level and redox state of intracellular iron. The regulatory small RNA (sRNA) RyhB has recently been shown to play a central role in adaptation to iron starvation, while the sRNA OxyS coordinates cellular response to oxidative stress. These regulatory sRNAs are well conserved in many bacteria and have been shown to be essential for establishing a successful infection. An overview of the different strategies used by bacteria to cope with iron starvation and oxidative stress is presented here.

PMID:
20393591
DOI:
10.1139/Y10-014
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center