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J Neurol Neurosurg Psychiatry. 2010 Jun;81(6):696-9. doi: 10.1136/jnnp.2009.173187. Epub 2010 Apr 14.

Sporothrix schenckii meningitis in AIDS during immune reconstitution syndrome.

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  • 1Evandro Chagas Clinical Research Institute (IPEC), Oswaldo Cruz Foundation (FIOCRUZ), Avenida Brasil, Rio de Janeiro, Brazil.


Sporotrichosis is a fungal disease usually restricted to the cutaneous and lymphatic systems. Visceral involvement is unusual. To date, only 21 cases of sporotrichosis meningitis have been reported, some of these associated with immunosuppression. According to the reported cases, difficulty establishing the correct diagnosis is almost the rule which, undoubtedly, is associated with a worse prognosis. In this report, two HIV infected patients are described who developed meningitis due to Sporothrix schenckii associated with immune reconstitution inflammatory syndrome. This is the first report of sporotrichosis meningitis associated with immune reconstitution inflammatory syndrome in AIDS patients.

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