Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Biol. 2010 Apr 13;20(7):R328-33. doi: 10.1016/j.cub.2010.01.044.

Sensing and signaling in antiviral innate immunity.

Author information

  • 1Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland. laoneill@tcd.ie

Abstract

Viruses are detected by the innate immune system, leading to the initiation of the anti-viral immune response via the production of type I interferons and inflammatory cytokines such as interleukin-1. Remarkable progress has been made over the past few years towards understanding the contribution of Toll-like receptors, RIG-I like receptors, NOD-like receptors and HIN-200 family members to viral detection. Furthermore, new complexities in the signaling pathways activated by these receptors continue to be revealed. Together, these new insights are leading to therapeutically useful information in the fight against viruses.

PMID:
20392426
DOI:
10.1016/j.cub.2010.01.044
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center