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Int J Tuberc Lung Dis. 2010 May;14(5):551-9.

Factors associated with treatment adherence in a randomised trial of latent tuberculosis infection treatment.

Author information

1
Pró-Reitoria de Saúde, Gama Filho University, Brazil. atrajman@gmail.com

Abstract

SETTING:

Randomised controlled trial of latent tuberculosis infection (LTBI) treatment in 10 clinics in Canada, Saudi Arabia and Brazil.

OBJECTIVE:

To identify early predictors of LTBI treatment adherence, including pre-treatment characteristics.

DESIGN:

Patients randomised to 4 months of rifampicin (RMP; n = 420) or 9 months of isoniazid (n = 427) were monitored for adherence using an electronic device. Outcomes were 1) treatment completion, defined as intake of >or=80% of the prescribed doses, and further categorised as completed within the allotted time or not; and 2) treatment regularity, measured by the time interval between doses. Relative risk (RR) and adjusted odds ratios (aOR) of patients' pre-treatment characteristics and adherence at first follow-up visit were calculated.

RESULTS:

Completion of treatment was higher with RMP (aOR 4.3, 95%CI 2.7-6.8). Early predictors (first follow-up visit) of non-adherence were late first visit attendance (RR for completion in time 0.9, 95%CI 0.8-0.98), >20% of missed doses (RR 0.4, 95%CI 0.3-0.6) and greater variation of hours between doses (0.209 vs. 0.131, P < 0.001). Serious adverse events were not associated with irregularity of treatment.

CONCLUSION:

The shorter RMP regimen was associated with better adherence. Patients with poor adherence could be identified at the first follow-up visit from their punctuality in follow-up, missed doses and variability of pill-taking.

PMID:
20392347
[Indexed for MEDLINE]

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