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Zebrafish. 2010 Mar;7(1):31-40. doi: 10.1089/zeb.2010.0650.

Oligonucleotide-based tools for studying zebrafish development.

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1
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

Abstract

Synthetic and nonnatural oligonucleotides have been used extensively to interrogate gene function in zebrafish. In this review, we survey the capabilities and limitations of various oligonucleotide-based technologies for perturbing RNA function and tracking RNA expression. We also examine recent strategies for achieving spatiotemporal control of oligonucleotide function, particularly light-gated technologies that exploit the optical transparency of zebrafish embryos.

PMID:
20392138
PMCID:
PMC2860060
DOI:
10.1089/zeb.2010.0650
[Indexed for MEDLINE]
Free PMC Article
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