Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors

ChemMedChem. 2010 May 3;5(5):674-7. doi: 10.1002/cmdc.201000030.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / toxicity
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Histone Deacetylase Inhibitors / chemical synthesis
  • Histone Deacetylase Inhibitors / chemistry*
  • Histone Deacetylase Inhibitors / toxicity
  • Humans
  • Pyrimidinones / chemical synthesis
  • Pyrimidinones / chemistry*
  • Pyrimidinones / toxicity
  • Sirtuins / antagonists & inhibitors*
  • Sirtuins / metabolism

Substances

  • Antineoplastic Agents
  • Histone Deacetylase Inhibitors
  • Pyrimidinones
  • Sirtuins