Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochem Genet. 2010 Jun;48(5-6):538-47. doi: 10.1007/s10528-010-9337-0.

Identification of a QTL for adipocyte volume and of shared genetic effects with aspartate aminotransferase.

Author information

1
Department of Human Ecology, University of Texas at Austin, 78712, USA. tbose@calpoly.edu <tbose@calpoly.edu>

Abstract

Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST.

PMID:
20390338
PMCID:
PMC2869397
DOI:
10.1007/s10528-010-9337-0
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center