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Cancer Metastasis Rev. 2010 Jun;29(2):273-83. doi: 10.1007/s10555-010-9220-9.

Senescent cells as a source of inflammatory factors for tumor progression.

Author information

1
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.

Abstract

Cellular senescence, which is associated with aging, is a process by which cells enter a state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive mechanism. Recent studies show that, despite the beneficial effects of cellular senescence, senescent cells can also exert harmful effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescent-associated secretory phenotype (SASP), which entails a striking increase in the secretion of pro-inflammatory cytokines. Here, we summarize our knowledge of the SASP and the impact it has on tissue microenvironments and ability to stimulate tumor progression.

PMID:
20390322
PMCID:
PMC2865636
DOI:
10.1007/s10555-010-9220-9
[Indexed for MEDLINE]
Free PMC Article

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