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Mar Drugs. 2010 Feb 23;8(2):359-72. doi: 10.3390/md8020359.

New lobane and cembrane diterpenes from two comorian soft corals.

Author information

1
Laboratoire de Chimie des Biomolécules et de l'Environnement, Centre de Phytopharmacie, Université de Perpignan, Perpignan Cedex, France. sabelle.bonnard@univ-perp.fr

Abstract

Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 1-3 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase.

KEYWORDS:

Lobophytum; Sarcophyton; acetylcholinesterase inhibitors; cembrane; lobane

PMID:
20390110
PMCID:
PMC2852843
DOI:
10.3390/md8020359
[Indexed for MEDLINE]
Free PMC Article

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