Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Cancer Res. 2010 May 1;16(9):2512-7. doi: 10.1158/1078-0432.CCR-09-2232. Epub 2010 Apr 13.

Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy.

Author information

  • 1Department of Research Pathology, Genentech, Inc., South San Francisco, CA 94080, USA.

Abstract

Signaling through the insulin-like growth factor receptor (IGF-1R) is required for neoplastic transformation by a number of oncogenes, and preclinical validation studies have suggested IGF-1R is an attractive target for anticancer therapy. A number of small molecules and antibodies targeting IGF-1R have entered clinical development, and early results have suggested that these agents have generally acceptable safety profiles as single agents. Some evidence of antitumor activity has also been reported. This review highlights key aspects of the IGF-1R signaling pathway that implicate it as an attractive therapeutic target in the management of cancer, as well as some key lessons that have emerged from early clinical development of anti-IGF-1R targeting agents. In addition, we consider the importance of selecting indications characterized by pathological alterations in the signaling pathway, rational selection of combinations based on signaling pathway interactions, and strategies for patient selection based on analysis of predictive biomarkers.

PMID:
20388853
DOI:
10.1158/1078-0432.CCR-09-2232
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center