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Hum Mol Genet. 2010 Apr 15;19(R1):R4-R11. doi: 10.1093/hmg/ddq142. Epub 2010 Apr 13.

Current status on Alzheimer disease molecular genetics: from past, to present, to future.

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1
Department of Molecular Genetics, Institute Born-Bunge, University of Antwerp, Antwerpen, Belgium.

Abstract

Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the three causal genes-amyloid precursor protein and presenilin 1 and 2 genes-and one risk gene apolipoprotein E (APOE), no single functional risk variant was identified. Discussing the possible involvement of rare alleles and other types of genetic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome-wide association studies.

PMID:
20388643
PMCID:
PMC2875058
DOI:
10.1093/hmg/ddq142
[Indexed for MEDLINE]
Free PMC Article
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