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J Nat Prod. 2010 May 28;73(5):976-9. doi: 10.1021/np900786s.

Utahmycins a and B, azaquinones produced by an environmental DNA clone.

Author information

1
Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA.

Abstract

Two new azaquinones, utahmycins A (1) and B (2), were isolated from cultures of Streptomyces albus J1704 transformed with the environmental DNA-derived Erd gene cluster. The structures of 1 and 2 were elucidated by spectroscopic analyses. The structure of 1 was confirmed by single-crystal X-ray diffraction analysis. Both metabolites appear to arise from the addition of a nitrogen atom to erdacin biosynthetic intermediates. Utahmycin A (1) is the first example of a biologically derived 1,3-dimethyl-2-azaanthraquinone.

PMID:
20387794
PMCID:
PMC2893554
DOI:
10.1021/np900786s
[Indexed for MEDLINE]
Free PMC Article

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