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Biomark Med. 2010 Feb;4(1):65-79.

Blood-based biomarkers of Alzheimer's disease: challenging but feasible.

Author information

1
Laboratory of Personality & Cognition, Intramural Research Program, National Institue on Aging, NIH, USA.

Abstract

Blood-based biomarkers present a considerable challenge: technically, as blood is a complex tissue and conceptually, as blood lacks direct contact with brain. Nonetheless, increasing evidence suggests that there is a blood protein signature, and possibly a transcript signature, that might act to increase confidence in diagnosis, be used to predict progression in either disease or prodromal states, and that may also be used to monitor disease progression. Evidence for this optimism comes partly from candidate protein studies, including those suggesting that amyloid-beta measures might have value in prediction and those studies of inflammatory markers that consistently show change in Alzheimer's disease, and partly from true proteomics studies that are beginning to identify markers in blood that replicate across studies and populations.

PMID:
20387303
PMCID:
PMC2863057
DOI:
10.2217/bmm.09.84
[Indexed for MEDLINE]
Free PMC Article

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