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Methods Mol Biol. 2010;629:87-91. doi: 10.1007/978-1-60761-657-3_6.

Systemic delivery of synthetic siRNAs.

Author information

1
Department of Comparative Medicine, Rikshospitalet-Radiumhospitalet, University Hospital, Oslo, Norway.

Abstract

RNA interference is a biological process for gene silencing that can be harnessed for the development of new drugs. However, a major obstacle to the use of small interfering RNAs (siRNAs) as therapeutics is their delivery across the plasma membrane of cells in vivo. A range of solutions for this challenge have been described, including cationic lipids, high-pressure injection, viral vectors, and chemical modifications of the siRNAs. This chapter describes cationic lipid delivery of siRNAs to adult mice.

PMID:
20387144
DOI:
10.1007/978-1-60761-657-3_6
[Indexed for MEDLINE]

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