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Pediatrics. 2010 May;125(5):e1241-5. doi: 10.1542/peds.2009-1815. Epub 2010 Apr 12.

Concurrent treatment of steroid-related mood and psychotic symptoms with risperidone.

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1
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.

Abstract

Corticosteroid treatment is an important therapeutic modality for many pediatric medical conditions including acute lymphoblastic leukemia. However, steroid-induced behavioral and mood abnormalities are common and potentially disabling adverse effects that have been widely reported in the pediatric literature. From this case series, we report the efficacy of risperidone in 3 children with acute lymphoblastic leukemia who developed steroid-related mood and psychotic symptoms during treatment with prednisone and dexamethasone. Risperidone is an effective short-term pharmacologic agent for controlling steroid-related psychiatric adverse effects when cessation or dose reduction of steroid therapy is not an option.

PMID:
20385646
DOI:
10.1542/peds.2009-1815
[Indexed for MEDLINE]
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