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Cancer Cell. 2010 Apr 13;17(4):311-2. doi: 10.1016/j.ccr.2010.03.013.

Prostate cancer: beta control your hormones.

Author information

1
Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. massimo_loda@dfci.harvard.edu

Abstract

Differentiation status influences the prognosis for localized prostate cancer. In this issue of Cancer Cell, Mak and coworkers describe a signaling pathway involving estrogen receptor beta (ERbeta) that governs whether prostate carcinoma cells maintain an epithelial phenotype or undergo epithelial-mesenchymal transition, suggesting that ERbeta would have prognostic or therapeutic value.

PMID:
20385354
DOI:
10.1016/j.ccr.2010.03.013
[Indexed for MEDLINE]
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