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Food Chem Toxicol. 2010 Jun;48(6):1753-6. doi: 10.1016/j.fct.2010.04.006. Epub 2010 Apr 10.

Effect of lead toxicity on coenzyme Q levels in rat tissues.

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Biochemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr-City, Cairo, Egypt.


Lead is a persistent and common environmental contaminant, which chiefly plays a significant role in modern industry. Coenzyme Q acts as electron and proton carrier in mitochondria and functions as an antioxidant in its reduced form (ubiquinol). To investigate the hazardous effects of lead on the coenzyme Q level, rats were injected i.p. with lead acetate (5 mg/kg b.wt. daily for 6 weeks). Our results showed that the levels of both oxidized (ubiquinone) and reduced (ubiquinol) forms of coenzyme Q(9) and Q(10) in serum, brain, liver and kidney of lead-treated rats are quite different depending on the organ tissue type.

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