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Bioorg Med Chem Lett. 2010 May 1;20(9):2892-6. doi: 10.1016/j.bmcl.2010.03.033. Epub 2010 Mar 10.

Identification of benzimidazole-based inhibitors of the mitogen activated kinase-5 signaling pathway.

Author information

1
Division of Medicinal Chemistry, School of Pharmacy, Duquesne University, 600 Forbes Ave., Pittsburgh, PA 15282, USA. flahertyp@duq.edu

Abstract

The MEK-signaling pathways are complex but critical signaling cascades that correlate an extracellular signaling event with internal cell processes. To date at least seven MEK isozymes have been identified. MEK5, in particular, is upregulated in multiple forms of tumors. Analysis of the EGF-induced MEK5 signaling cascade in cultured HEK cells has identified compounds that can inhibit MEK5 phosphorylation of ERK5; observed biological activity is dependent on chemical variation.

PMID:
20382528
DOI:
10.1016/j.bmcl.2010.03.033
[Indexed for MEDLINE]

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