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Vaccine. 2010 May 21;28(23):3956-62. doi: 10.1016/j.vaccine.2010.03.047. Epub 2010 Apr 9.

Echinacea purpurea aerial extract alters course of influenza infection in mice.

Author information

1
Division of Infectious Diseases, Weill Cornell Medical College, NY, United States.

Abstract

Influenza infection is a major clinical problem and Echinacea purpurea, a widely consumed botanical product, is purported to alter the course of respiratory infections including influenza. Mice infected with WSN influenza A and treated with E. purpurea polysaccharide extract had less weight loss than untreated mice but similar pulmonary viral titers. Echinacea-treated mice had lower systemic and pulmonary KC and IL-10 levels and lower systemic IFN-gamma levels following influenza infection. These suggest that E. purpurea alters the clinical course of influenza infection in mice through modulation of cytokines and not direct antiviral activity.

PMID:
20382242
PMCID:
PMC3016056
DOI:
10.1016/j.vaccine.2010.03.047
[Indexed for MEDLINE]
Free PMC Article

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